Virus clearance and carryover study on twin-column (continuous chromatography) system  

YMC
Owner:YMC

Webinar Details

On its pathway to clinical and commercial scale, multicolumn capture chromatography requires development of scalable models for virus validation studies. In this study, retro‐ (X‐MuLV) and parvo‐virus (MVM) clearance in twin‐column continuous capture chromatography (CaptureSMB) was investigated and a surrogate model was developed using standard batch mode chromatography. The results showed that the log reduction values (LRVs) achieved during CaptureSMB were also comparable to the LRVs obtained using standard batch capture chromatography and that virus carryover could be well controlled. Further this presentation also shows assessments of the impact of resin cleaning strategy and the duration of clean‐in‐place solution exposure on virus carryover.

This is a ~20 minute presentation after which live audience Q&A will ensue.

NOTE: this is one in a series of ~15 webinars on twin-column “continuous” chromatography technology by YMC/ChromaCon. View all on www.biolingo.com search term “YMC”.

SpeakerThomas Müller-Späth, Ph.D
Thomas Müller-Späth, Ph.D, holds the position CTO at YMC ChromaCon AG, Switzerland. Thomas is inventor of 10+ patents and has authored and co-authored 30+ scientific articles and book chapters on continuous chromatography for biopharmaceuticals and downstream processing. Thomas frequently presents at international conferences as speaker and also co-chairs workshops on continuous chromatography. Thomas studied chemical engineering at the Technical University of Hamburg, Germany, and at the University of California, Berkeley. Thomas gained further R&D experience at Bayer Healthcare in Berkeley, CA, and Beiersdorf , in Hamburg Germany. He obtained his PhD in 2008 in the area of the multi-column-technology for the purification of proteins at the Swiss Federal Institute of Technology (ETH Zurich) in the group of Prof. Morbidelli, where until recently he is also active as a Scientific Advisor.
ModeratorGerard Gach
Gerard Gach has over 30 years in industry and is presently the Chief Marketing Officer (CMO) of YMC's bio/pharma systems’ business. His present role is identifying new growth segments within the life science space, providing strategic direction and aligning industry collaborators and developing product value insights. Previously Gerard spent 12+ years with General Electric as Global New Products and Strategy Manager. Previously he was with Pall (Danaher), Koch Membrane and Osmonics (now Suez) in varying leadership capacities.

Date/Time

Eastern Time (US and Canada)

May 19, 2020 12:00 am GMT-04:00

Beijing, Shanghai (China)

May 19, 2020 12:00 pm GMT+08:00

Berlin (Germany)

May 19, 2020 6:00 am GMT+02:00

Duration

Short < 30 min

Languages

English

Webinar Type

Recorded